Source: NeuroImage, 2017, Vol 152 p. 207-220
Follow this link for the abstract
Date of publication: May 2017
Publication type: Journal article
In a nutshell: Impairments in motor automaticity cause patients with Parkinson’s disease to rely on attentional resources during gait, resulting in greater motor variability and a higher risk of falls. Although dopaminergic circuitry is known to play an important role in motor automaticity, little evidence exists on the neural mechanisms underlying the breakdown of locomotor automaticity in Parkinson’s disease. Overall, this study demonstrates that dopamine ameliorates gait automaticity in Parkinson’s disease by altering striatal, limbic and cerebellar processing, thereby informing future therapeutic avenues for gait and falls prevention.
Length of publication: 13 pages
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