Dopamine depletion in Parkinsons alters brain processing, impairing gait automaticity


Source: NeuroImage, 2017, Vol 152 p. 207-220

Follow this link for the abstract

Date of publication: May 2017

Publication type: Journal article

In a nutshell: Impairments in motor automaticity cause patients with Parkinson’s disease to rely on attentional resources during gait, resulting in greater motor variability and a higher risk of falls. Although dopaminergic circuitry is known to play an important role in motor automaticity, little evidence exists on the neural mechanisms underlying the breakdown of locomotor automaticity in Parkinson’s disease. Overall, this study demonstrates that dopamine ameliorates gait automaticity in Parkinson’s disease by altering striatal, limbic and cerebellar processing, thereby informing future therapeutic avenues for gait and falls prevention.

Length of publication: 13 pages

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